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Network Immunology: Developing Products based on Immune Network Theory Neural Networks and Immune Networks?
 
Network Immunology: Developing Products based on Immune Network Theory

Network Immunology: Developing Products based on Immune Network Theory

Network Immunology Inc. is a privately owned Vancouver based biotechnology company, consisting of a team of individuals who are committed to developing solutions to some of the world’s most pressing health issues. The HIV vaccine and therapeutic products being developed are based on Dr. Geoffrey W. Hoffmann’s symmetrical immune network theory, which he has developed over [...]

Network Immunology: Developing Products based on Immune Network Theory
Neural Networks and Immune Networks?

Neural Networks and Immune Networks?

It has been known for quite some time, that the brain is a network of neurons. Scientists in the field of Network Immunology have discovered that the immune system also functions as a network of cells. Both networks have memory, and the ability to learn from experience. Both networks possess a distinct sense of self, and the ability [...]

Neural Networks and Immune Networks?
Network Immunology: Developing Products based on Immune Network Theory

Network Immunology: Developing Products based on Immune Network Theory

Network Immunology Inc. is a privately owned Vancouver based biotechnology company, consisting of a team of individuals who are committed to developing solutions to some of the world’s most pressing health issues.

The HIV vaccine and therapeutic products being developed are based on Dr. Geoffrey W. Hoffmann’s symmetrical immune network theory, which he has developed over a period of 42 years. This theory describes how the immune system functions and learns as a network of interacting immune system cells and antibodies.

What are the major premises of immune network theory?

Immune network theory states that the “recognizers” of the immune system (the lymphocytes and antibodies) don’t only recognize foreign entities, but also recognize and interact with each other.  Understanding these network interactions of the system is ultimately key to understanding the enormous issues of HIV, autoimmunity, organ rejection and cancer.

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Neural Networks and Immune Networks?

Neural Networks and Immune Networks?

It has been known for quite some time, that the brain is a network of neurons.

Scientists in the field of Network Immunology have discovered that the immune system also functions as a network of cells.

Both networks have memory, and the ability to learn from experience.

Both networks possess a distinct sense of self, and the ability to differentiate, between self and other.

Network Immunology’s Chief Scientist, Geoffrey W. Hoffmann, who is both a physicist and immunologist by background, has discovered a mathematical equation that unites the two systems.   They are separate, yet interconnected systems, that function along the same set of mathematical principles.

Network Immunology is the only company in the world, that is dedicated to building on this network framework of the immune system, and commercializing technologies that emerge from it.

Technologies under development include a preventive HIV vaccine, and a therapeutic for HIV positive individuals. There is now data for both of these products.

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Dr. Sybille Muller and Dr. Heinz Kohler join team at Network Immunology

Dr. Sybille Muller and Dr. Heinz Kohler join team at Network Immunology

Two experienced immunologists in the field of immune network science, Dr. Sybille Muller and Dr. Heinz Kohler, have joined Network Immunology.  Dr. Muller has been appointed to the Board of Directors, and Dr. Heinz Kohler has been appointed Chairman of the Scientific Advisory Board.  They discovered and researched the NetVac™ molecule that is a major component of the Network Immunology HIV vaccine.

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Dr. Matthew Parsons of McGill University joins Scientific Advisory Board

Dr. Matthew Parsons of McGill University joins Scientific Advisory Board

Dr. Matthew Parsons of McGill University has been appointed to the Scientific Advisory Board of Network Immunology. Dr. Parsons has contributed to important research around the NetVac™ molecule that is part of the HIV vaccine that Network Immunology is developing.

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A Brief History of Immune Network Theory: The Reemergence of a Forgotten Paradigm

A Brief History of Immune Network Theory: The Reemergence of a Forgotten Paradigm

The network theory of immunology is not currently the predominant paradigm of immunology. The framework emerged in the mid 1970’s.  Later, in 1984, a Danish immunologist by the name of Niels Kaj Jerne, was awarded the Nobel Prize for his immune network “hypothesis”.  He was the first to propose that the antibodies of the system not only recognized foreign antigens, but also recognized and interacted with each other, as part of a network.

Jerne had realized, that, just as the brain is a network of neurons, that could remember, and learn from experience, so is the immune system, a network, of cells and antibodies, that also remember and learn from experience.  And just as the brain has a profound sense of “self”, and an ability to distinguish between “self”, and other, so does the immune system possess this sense of “self”, and the ability to distinguish between what is “self” or part of the body, and what is foreign.

However, in the early 1980s, confusion arose around a protein called IJ, which is the central regulating unit of the immune system in the context of network theory. This is to say that, within the network framework, IJ is a major part of the central core, regulating unit, or “self”, of the system.

Immunologists had mapped IJ to a precise point in the genome but they soon found that the gene to express IJ was missing from the sequence. This came to be known as the IJ paradox. This problem regarding IJ baffled immunologists at the time, to the extent that they threw out the baby with the bathwater. In other words, they walked away from the theory because of the confusion around IJ which, as a central component of the system, is crucial for the theory to work.  Almost all immunologists from then onward, chose to shift their focus toward the details of the system, as opposed to developing this framework for understanding the system as a whole.

In contrast, Network Immunology’s Chief Scientist, Dr. Geoffrey Hoffmann, was captivated by this fundamental riddle, and turned his focus towards resolving IJ.  In 1994 he published the solution to the IJ paradox in a peer reviewed journal.  However, by then, virtually the entire field of immunology had moved away from network theory, and the attempt to understand the larger picture of immune system regulation.  They had moved on, to focus on the details of the system.   Hoffmann, in contrast, continued to develop the immune network theory, applying his background in physics, and mathematical modeling.

An extension to the theory eventually led to a novel HIV vaccine that Network Immunology is developing for protection from multiple strains of HIV.

Today, Network Immunology is the only company in the world, that represents the Network Theory of the immune system, and technologies emerging from it.

For further scientific information, feel free to read the introduction and contents section of Dr. Hoffmann’s book on immune network theory.

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Network Immunology Announces MAB3™: A Monoclonal Antibody Based Technology for the Prevention and Treatment of Autoimmune Diseases

Network Immunology Announces MAB3™: A Monoclonal Antibody Based Technology for the Prevention and Treatment of Autoimmune Diseases

Network Immunology’s Chief Scientist, Geoffrey W. Hoffmann, has discovered a way to make a kind of antibody for humans that has been shown in studies with mice to be intimately associated with the suppression of the immune system.  Network Immunology has filed a patent application for the use of this kind of antibody in the prevention and treatment of autoimmunity.

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Network Immunology Inc. Reports Filing of New Intellectual Property

Network Immunology Inc. Reports Filing of New Intellectual Property

On January 4th, 2011, Network Immunology Inc. filed provisional patent applications for it’s HIV vaccine and organ transplantation technologies. Both of these technologies have emerged from recent developments in Network Theory as applied to the immune system, and are closely related to each other at the level of the fundamental science. This was soon followed by a patent application for its MAB3 technology. On January 4th, 2012, the Company filed three Patent Convention Treaty applications, one for each of its technologies.

Network Immunology Inc. is seeking private equity financing in order to develop these technologies as quickly as possible.

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